АР19680576 – Development of a multifunctional wound-healing polymer composite material (PCM) of prolonged action for medical purposes
Purpose: Development of a multifunctional wound-healing 3D polymer composite material with prolonged action, based on bentonite modified with silver nanoparticles, a biopolymer and an active drug.
Relevance: The economic efficiency or significance of the work is ensured by the use of available natural bentonite clays from a Kazakhstani deposit and the production of a filler based on them for 3D-PCM modified with silver nanoparticles.
Scientific supervisor: Doctor of Chemical Sciences, Associate Professor, Aigul Zh Kerimkulova
Results obtained: The study involved a comprehensive physicochemical characterization of natural bentonites from Kazakhstan and the development of methods for their modification and activation. A green synthesis approach for silver nanoparticles and their intercalation into clay structures was optimized, resulting in stable nanocomposites with strong antimicrobial properties. Based on biopolymers such as gelatin, starch, and CMC, 3D polymer composite materials with immobilized drugs were developed. The obtained materials demonstrated high biocompatibility, mechanical stability, and prolonged antiseptic effects. A synergistic interaction between silver nanoparticles, drugs, and the clay-polymer matrix was experimentally confirmed. The proposed technology offers a sustainable and effective solution for the development of advanced medical materials
List of publications with links to them
- Kabdrakhmanova S.K. et al. Bentonite-based composites in medicine: synthesis, characterization, and applications // Journal of Composites Science. – 2025. – Vol. 9, No. 6. – P. 310. DOI: https://doi.org/10.3390/jcs9060310
- Kerimkulova A. et al. Qualitative assessment of the use of Kazakhstan montmorillonite clays as sorbent carriers for pharmaceutical substances // Physical Sciences and Technology. – 2025. – Vol. 12, No. 1–2. – P. 121–133. DOI: https://doi.org/10.26577/phst202512112
- Aryp K., Kabdrakhmanova S., Nauryzova S., Shaimardan E., Kantay N., Kerimkulova A.Zh., Beisebekov M.M., Kukhareva A.D., Berdibay N. Acid modification of bentonites Kalzhat and Orta Tentek and study their physicochemical properties // Вестник НЯЦ РК. – 2025. DOI: https://doi.org/10.52676/1729-7885-2025-3-77-85