AP08857516 – Metal-containing ionic liquids in agrochemistry

The aim of the Project is the synthesis of metal-containing bifunctional ionic liquids based on the biological active substances to determine candidate substances for agricultural chemistry (plant growth stimulants, adaptogens, root formation stimulants, etc.).

The relevance of the project: The project focuses on the development of new efficient and environmentally friendly agrochemicals based on ionic liquids, addressing a key challenge in modern agriculture. The use of metal-containing ionic compounds enables targeted tuning of properties and the creation of dual-function, long-acting agents. The project will contribute to reducing Kazakhstan’s dependence on imported agrochemicals and support domestic production. The results will advance green chemistry and sustainable technologies. Overall, the project is expected to deliver significant socio-economic benefits through improved crop productivity and agricultural efficiency.

Scientific adviser:  Ph.D., Associate Professor, Khadichakhan S Rafikova

Results obtained: Within the research project, new ionic compounds based on dimedrol and naftifine were synthesized using classical, ultrasound, and microwave-assisted methods. The synthesized compounds were characterized by IR and NMR spectroscopy as well as thin-layer chromatography. Antibacterial activity studies revealed that several compounds are effective against S. aureus, E. coli, and B. subtilis. The complexation ability of the compounds with metal ions was investigated, resulting in the formation of metal-containing complexes. The plant growth-stimulating activity of both initial and metal-containing compounds was evaluated. All tasks outlined in the project plan were fully completed. The results obtained can be used to expand the pool of promising candidate substances for agrochemical applications and the development of green technologies.

List of publications with links to them

1. Rafikova K., Meriç N., Güzel R., Arslan N., Binbay N. E., Kayan C., Okumus V., Zazybin A., Seilkhanov T., Binbay V., Aydemir M. Transition metals of arene derivatives with functionalized ionic liquid: DFT investigation, biological applications and electrochemical behavior of complexes // Inorganica Chimica Acta. – 2022. – Vol. 542. – Art. 121142. – DOI: https://doi.org/10.1016/j.ica.2022.121142.
2. Karakaş D., Rafikova K., Baysal A., Meriç N., Zazybin A., Kayan C., Işik U., Saparbaykyzy I. S., Durap F., Aydemir M. Ketone transfer hydrogenation reactions catalyzed by catalysts based on a phosphinite ligand // Journal of Coordination Chemistry. – 2022. – P. 1–14. – DOI: https://doi.org/10.1080/00958972.2022.2054339.
3. Zazybin A., Aydemir M., Rafikova K., Islam S., Kamshyger Y., Kayan C., Meriç N., Isik U., Belyankova Y., Dauletbakov A., Alpiyeva A. Ruthenium catalysts for enantioselective transfer hydrogenation of ketones // The 9th Tokyo Conference on Advanced Catalytic Science and Technology. – Tokyo, 2022. – P. 2067.
4. Islam Sh. S., Rafikova Kh. S., Ryspaeva S. B., Kerimkulova A. Zh., Kozhaisakova M. A. Extraction of sulfur compounds from motor fuel with deep eutectic solvents // Известия НАН РК. Серия химии и технологии. – 2022. – № 4.
5. Tursynbek S. Ye., Rafikova Kh. S., Akimbek A. O., Kamshyger Ye., Jamalova G. A., Naukanova M. N. Uwave-2000 as an effective equipment for microwave-assisted synthesis of N,N-diethyl-2-(mesitylamino)-N-benzyloxoethanamonium chloride – a compound with plant growth regulating activity // Вестник Казахстанско-Британского технического университета. – 2022. – № 3 (62). – P. 45–53.
6. Baktybayeva L., Daulet G., Zazybin A., Yu V., Ostapchuk Y., Perfilyeva Y., Kali A., Abdolla N., Malmakova A., Baktybai N., Temirbekova Z., Rafikova Kh. Stimulation of B-lymphopoiesis by administration of a trimecaine-based ionic compound in cyclophosphamide-induced hematopoietic-depressive model // Molecules. – 2022.
7. Dauletbakov A., Baktybaeva L., Giner B., Nuranov A., Zolotareva D., Boranova A., Eskaraeva B., Zazybin A. Synthesis, myelostimulating activity and ecotoxicological studies of ionic compounds based on diphenhydramine // 21st Tetrahedron Symposium. – Gothenburg, 2021. – P. P2.14.
8. Тен А., Зазыбин А., Ю В., Анапияев Б. Б., Рафикова Х. С., Искакова К., Айдемир М., Даулетбаков А., Белянкова Е., Золотарева Д., Сагимбаева А., Бейсенбек Е. Йодид 1-пропил-1-(2-метил-3-оксо-3-(п-толил)пропилил)пиперидин-1-иума, обладающий ростостимулирующими и радиопротекторными свойствами: заявка на патент РК № 2021/0513.1 от 25.08.2021.
9. Любушкина И. В., Поморцев А. В., Полякова М. С., Арбузова Г. А., Уколова И. В., Войников В. К., Анапияев Б. Б. Сравнение процесса дыхания у донорных растений озимой пшеницы сорта Иркутская и каллусов, полученных из данного сорта в культуре изолированных пыльников // Известия Иркутского государственного университета. Серия: Биология. Экология. – 2021. – Т. 37. – С. 3–15. – DOI: https://doi.org/10.26516/2073-3372.2021.37.3.
10. Sagyman Zh., Han X., Anapiyayev B. B., Tao F., Xu P. Bacterial diversity analysis in Kazakh fermented milks Shubat and Ayran by combining culture-dependent and culture-independent methods // LWT – Food Science and Technology. – 2021. – Vol. 141. – Art. 110877. – DOI: https://doi.org/10.1016/j.lwt.2021.110877.
11. Giner B., Mergenbayeva S., Lomba L., Rafikova K., Dauletbakov A., Belyankova Y., Seilkhanov T., Zazybin A. Synthesis and ecotoxicological studies of ionic compounds based on tolperisone, diphenhydramine and trimecaine // ChemistrySelect. – 2020. – Vol. 5. – P. 1–7. – DOI: https://doi.org/10.1002/slct.202001771.