AP26199303 "Development of Novel Magnetic Nanocomposite particles for Enhanced Targeted Drug Delivery"

Relevance

Improving the efficiency and safety of drug delivery remains a critical challenge in modern biomedicine. Magnetic nanocomposite particles (MNCPs) enable targeted delivery, controlled release, and reduced side effects. The relevance of this project lies in optimizing MNCP properties and regulating protein corona formation to develop advanced drug delivery systems, enhancing therapeutic efficacy and facilitating clinical application.

Purpose

Development of novel protein-repellent magnetic nanocomposite particles for efficient drug delivery by investigating their interfacial properties, drug release efficiency and protein corona inhibition using the bubble-rising method.

Expected and achieved results

Expected results: synthesis and optimization of magnetic nanoparticles, enhanced drug-loading and controlled release efficiency, improved stability and targeting via surface functionalization, inhibition of protein corona formation, development of kinetic and mass transfer models.

Achieved results: MNCPs were synthesized with optimized surface properties, the Rising Bubble method was applied for the first time, drug release mechanisms and mass transfer models were developed, and novel protein-resistant magnetic nanoparticles were created.

Research team members with their identifiers (Scopus Author ID, Researcher ID, ORCID, if available) and links to relevant profiles